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Home / Antibodies

MAD2L1 Antibody

SKU : BHA10558909

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA249117
Alternative Names	Mitotic spindle assembly checkpoint protein MAD2A; HsMAD2; Mitotic arrest deficient 2-like protein 1; MAD2-like protein 1; MAD2L1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.Li Y., Science 274:246-248(1996).Gemma A., Lung Cancer 32:289-295(2001).Jin D.-Y., Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MAD2L1.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. Li Y., Science 274:246-248(1996). Gemma A., Lung Cancer 32:289-295(2001). Jin D.-Y., Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MAD2L1 protein.
Subcellular Location	Nucleus, Chromosome, centromere, kinetochore, Cytoplasm, Cytoplasm, cytoskeleton, spindle pole

Uniprot	Q13257
Database Links	HGNC:6763 OMIM:601467 KEGG:hsa:4085 STRING:9606.ENSP00000296509 UniGene:Hs.591697
Function	Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Pathway	Cell cycle
Protein Families	MAD2 family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558909	CSB-PA249117	100ul	$297		Add to Cart

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