Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.Browning J.L., Cell 72:847-856(1993).Warzocha K., Biochem. Biophys. Res. Commun. 238:273-276(1997).Neville M.J., J. Immunol. 162:4745-4754(1999).
Host
Rabbit
Immunogen
Synthesized peptide derived from C-terminal of Human TNFC.
Raised In
Rabbit
Reactivity
Human, Mouse
Regulatory
RUO
Relevance
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
Browning J.L., Cell 72:847-856(1993). Warzocha K., Biochem. Biophys. Res. Commun. 238:273-276(1997). Neville M.J., J. Immunol. 162:4745-4754(1999).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total TNFC protein.
Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.
Pathway
NF-kappa B signaling pathway
Protein Families
Tumor necrosis factor family
Tissue Specificity
Spleen and thymus.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.