The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
A portion of amino acids 234-260 from the human protein was used as the immunogen for this LOX antibody.
Isotype
Mouse IgG2b
Species Reactivity
Human
Note
Titration of the LOX antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Uniprot
P28300
Format
Ascites
Purity
Ascites
Storage
Aliquot the LOX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.