Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).Hiramatsu T., J. Biol. Chem. 278:49438-49447(2003).Wen X.-Y., Hum. Mol. Genet. 12:1131-1143(2003).Hattori M., Nature 405:311-319(2000).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human LIPI.
Involvement In Disease
Hypertriglyceridemia, familial (FHTR)
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Hiramatsu T., J. Biol. Chem. 278:49438-49447(2003). Wen X.-Y., Hum. Mol. Genet. 12:1131-1143(2003). Hattori M., Nature 405:311-319(2000).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total LIPI protein.
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Protein Families
AB hydrolase superfamily, Lipase family
Tissue Specificity
Expressed in testis. Expressed exclusively at the connecting piece of the sperm.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.