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Home / Primary Antibodies

LIN28A Antibody

SKU : BHA10557522

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA586531
Alternative Names	CSDD1; LIN-28; LIN28A; ZCCHC1;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.Heo I., Joo C., Mol. et al., Cell 32:276-284(2008) Heo I., Joo C., Kim Y.-K., et al., Cell 138:696-708(2009) Viswanathan S.R., Powers J.T., et al., Nat. Genet. 41:843-848(2009)
Host	Rabbit
Immunogen	Peptide sequence around aa. 1~5 (M-G-S-V-S) derived from Human Lin28
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. Heo I., Joo C., Mol. et al., Cell 32:276-284(2008) Heo I., Joo C., Kim Y.-K., et al., Cell 138:696-708(2009) Viswanathan S.R., Powers J.T., et al., Nat. Genet. 41:843-848(2009)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Lin28 protein.
Subcellular Location	Cytoplasm, Rough endoplasmic reticulum, Cytoplasm, P-body, Cytoplasm, Stress granule, Nucleus, nucleolus

Uniprot	Q9H9Z2
Database Links	HGNC:15986 OMIM:611043 KEGG:hsa:79727 STRING:9606.ENSP00000254231 UniGene:Hs.86154
Function	RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism
Protein Families	Lin-28 family
Tissue Specificity	Expressed in embryonic stem cells, placenta and testis. Tends to be up-regulated in HER2-overexpressing breast tumors.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557522	CSB-PA586531	100ul	$297		Add to Cart

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