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Home / Antibodies

LFNG Antibody

SKU : BHA10558270

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA570737
Alternative Names	beta-1; 3-N-acetylglucosaminyltransferase lunatic fringe; EC 2.4.1.222; LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Categories	Primary Antibodies
Clonality	polyclonal
Description	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning By similarity.Johnston S.H., Development 124:2245-2254(1997).Cole S.E., Dev. Cell 3:75-84(2002).Shimizu K., J. Biol. Chem. 276:25753-25758(2001)
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human LFNG.
Involvement In Disease	Spondylocostal dysostosis 3, autosomal recessive (SCDO3)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning By similarity. Johnston S.H., Development 124:2245-2254(1997). Cole S.E., Dev. Cell 3:75-84(2002). Shimizu K., J. Biol. Chem. 276:25753-25758(2001)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total LFNG protein.
Subcellular Location	Golgi apparatus membrane, Single-pass type II membrane protein

Uniprot	Q8NES3
Database Links	HGNC:6560 OMIM:602576 KEGG:hsa:3955 STRING:9606.ENSP00000222725 UniGene:Hs.159142
Function	Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1
Pathway	Notch signaling pathway
Protein Families	Glycosyltransferase 31 family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558270	CSB-PA570737	100ul	$297		Add to Cart

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