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Home / Antibodies

LCK Antibody (F53783)

SKU : BHA17119865

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Mfr.No.	F53783-0.1ML
Clonality	Monoclonal (mouse origin)
Description	Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are goveed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP.
Formulation	In ascites with 0.09% sodium azide
Host	Mouse
Immunogen Region	Purified His-tagged protein was used to produced this monoclonal LCK antibody.
Isotype	Mouse IgG1
Species Reactivity	Human
Note	Titration of the LCK antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Uniprot	P06239

Format	Ascites
Purity	Ascites
Storage	Aliquot the LCK antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Description	Weste blot: 1:5000

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17119865	F53783-0.1ML	0.1 ml	$389		Add to Cart

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