Rabbit Anti-Human LC3A Polyclonal

Mfr.No.	SPC-613, SPC-613D, SPC-613D-A390, SPC-613D-A488, SPC-613D-A594, SPC-613D-ALP, SPC-613D-APC, SPC-613D-BI, SPC-613D-FITC, SPC-613D-HRP, SPC-613D-PCP, SPC-613D-RPE, SPC-613S
Immunogen Species	Human
Alternative Names	MAP1 light chain 3 like protein 1 Antibody, Map1lc3a Antibody, MAP1BLC3 Antibody, Autophagy-related ubiquitin-like modifier LC3 A Antibody, MAP1LC3A Antibody, LC3A Antibody, Microtubule-associated proteins 1A and 1B, light chain 3 Antibody, MAP1ALC3 Antibody, MAP1A/1B light chain 3 A Antibody, MAP1A/MAP1B light chain 3 A Antibody, Microtubule-associated protein 1 light chain 3 alpha Antibody, LC3 Antibody, Microtubule-associated proteins 1A/1B light chain 3A Antibody, Autophagy-related protein LC3 A Antibody, MAP1A/MAP1B LC3 A Antibody, ATG8E Antibody, MLP3A_HUMAN Antibody, MAP1 light chain 3-like protein 1 Antibody, Microtubule associated proteins 1A/1B light chain 3 Antibody
Categories	Antibodies
Cellular Localization	Cytoskeleton, Lipid-Anchor, Cytoplasm, Endomembrane System, Cytoplasmic Vesicle, Autophagosome Membrane, Autophagosome
Certificate Of Analysis	A 1:1000 dilution of SPC-613 was sufficient for detection of LC3A in 15 ug of Human HeLa Cell Lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Clonality	Polyclonal
Description	Rabbit Anti-Human LC3A Polyclonal
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Host	Rabbit
Gross Weight (kg)	1.4
Immunogen	Synthetic peptide from the N-terminal of Human LC3A (aa. 1-12), Homo Sapiens (Human)
Immunogen Region	Synthetic peptide from the N-terminal of Human LC3A (aa. 1-12)
Launch Date	2016/08/29
Net Weight (g)	0.1
Reactivity	Rat, Mouse, Human
Recombinant	FALSE
Regulatory	RUO
Species	Homo Sapiens (Human)
Species Reactivity Medium	Mouse, Rat, Human
Tissue Specificity	Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

Swissprot	Q9H492
Accession Number	NP_115903.1
Gene Id	84557
Target	LC3A
Research Area	Cancer, Autophagy, Cell Signaling, Cardiovascular System, Heart, Neuroscience

Buffer	PBS, 50% glycerol, 0.09% sodium azide
Concentration	1 mg/ml
Dilutions	WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification	Peptide Affinity Purified
Purity	Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
Scientific Background	Light chain 3 (LC3) is a microtubule-associated protein with an approximate molecular mass of 17kDa, and can be found ubiquitously throughout mammalian tissue. LC3 plays a role in autophagy; once the autophagic process is initiated in a cell, LC3 is conjugated to phosphatidylethanolamine to form LC3-II. This molecule is recruited to the autophagosome at the time of fusion with lysosomes, and LC3-II in autolysosomal lumen is degraded. Therefore, monitoring LC3 is an important tool for detecting autophagy and autophagy-related processes. LC3A is one of three isoforms which exhibits abundant expression in the heart, brain, liver, skeletal muscle, and testis but is absent in thymus and peripheral blood leukocytes.
Shipping Temperature	Blue Ice or 4°C
Specificity	Detects ~14 kDa. Band at 50 kDa is LC3A complex.
Storage	-20ºC
Storage Buffer	PBS, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature	-20°C

Applications	WB, ICC/IF
Description	WB ; ICC ; IF
Dilution	WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Product Manual	SDS
SDS

Reference	1. Tanida I., Ueno T., & Kominami E. (2008) Methods Mol Biol. 445:77-88. 2. He H., et al. (2003) J Biol Chem. 278(31): 29278-87.

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Combination SKU	Supplier No.	Conjugate	Size	Your price
BHA11908242-1	SPC-613D	Unconjugated	100 ug	$331	Add to Cart
BHA11908242-2	SPC-613D-A390	ATTO 390	100 ug	$385	Add to Cart
BHA11908242-3	SPC-613D-A488	ATTO 488	100 ug	$384	Add to Cart
BHA11908242-4	SPC-613D-A594	ATTO 594	100 ug	$384	Add to Cart
BHA11908242-5	SPC-613D-ALP	Alkaline Phosphatase	100 ug	$377	Add to Cart
BHA11908242-6	SPC-613D-APC	APC	100 ug	$383	Add to Cart
BHA11908242-7	SPC-613D-BI	Biotin	100 ug	$380	Add to Cart
BHA11908242-8	SPC-613D-FITC	FITC	100 ug	$375	Add to Cart
BHA11908242-9	SPC-613D-HRP	HRP	100 ug	$371	Add to Cart
BHA11908242-10	SPC-613D-PCP	PerCP	100 ug	$383	Add to Cart
BHA11908242-11	SPC-613D-RPE	RPE	100 ug	$381	Add to Cart
BHA11908242-12	SPC-613S	Unconjugated	12 ug	$44	Add to Cart

LC3A Antibody - SPC-613

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