Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.Kallunki T., J. Biol. Chem. 266:221-228(1991).Pikkarainen T., J. Biol. Chem. 263:6751-6758(1988).Fukushima Y., Cytogenet. Cell Genet. 48:137-141(1988).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human LAMC1.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Kallunki T., J. Biol. Chem. 266:221-228(1991). Pikkarainen T., J. Biol. Chem. 263:6751-6758(1988). Fukushima Y., Cytogenet. Cell Genet. 48:137-141(1988).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total LAMC1 protein.
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Pathway
PI3K-Akt signaling pathway Focal adhesion
Tissue Specificity
Found in the basement membranes (major component).
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.