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Home / Antibodies

Lambda Light Chain Antibody / Lambda Antibody (V3261SAF)

SKU : BHA17124920

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NSJ Bioreagents

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Mfr.No.	V3261SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	Antibodies are produced by B lymphocytes, each expressing only one class of light chain. Once set, light chain class remains fixed for the life of the B lymphocyte. In a healthy individual, the total kappa to lambda ratio is roughly 3:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of neoplasm.Individual B-cells in lymphoid tissue possess either kappa or lambda light chains, but never both together. Specific rearrangement of lambda light chain of immunoglobulins can lead to loss of some protein coding genes, which does not seem to be functionally relevant (while functionally relevant miR-650 can be overexpressed). Using immunohistochemistry, it is possible to determine the relative abundance of B-cells expressing kappa and lambda light chains. If the lymph node or similar tissue is reactive, or otherwise benign, it should possess a mixture of kappa positive and lambda positive cells. If, however, one type of light chain is significantly more common than the other, the cells are likely all derived from a small clonal population, which may indicate a malignant condition, such as B-cell lymphoma. (Wiki)
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	IgG purified from human serum was used as the immunogen for this Lambda Light Chain antibody.
Isotype	Mouse IgG1, kappa
Species Reactivity	Human
Note	The optimal dilution of the Lambda Light Chain antibody for each application should be determined by the researcher.

Uniprot	P01701, P01842

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the Lambda Light Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	WB, FACS, IF, IHC-P
Description	Flow cytometry: 0.5-1ug/million cells,Immunofluorescence: 1-2ug/ml,Weste blot: 0.5-1ug/ml,Immunohistochemistry (FFPE): 0.5-1ug/ml for 30 min at RT

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17124920	V3261SAF-100UG	100 ug	$499		Add to Cart

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