Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.Wewer U.M., Genomics 24:243-252(1994).Iivanainen A., Matrix Biol. 14:489-497(1995).Zenker M., Hum. Mol. Genet. 13:2625-2632(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human LAMB2.
Involvement In Disease
Pierson syndrome (PIERSS); Nephrotic syndrome 5 with or without ocular abnormalities (NPHS5)
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Wewer U.M., Genomics 24:243-252(1994). Iivanainen A., Matrix Biol. 14:489-497(1995). Zenker M., Hum. Mol. Genet. 13:2625-2632(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total LAMB2 protein.
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
Pathway
PI3K-Akt signaling pathway Focal adhesion
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.