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Home / Primary Antibodies

KSR2 Antibody

SKU : BHA10559331

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA581207
Alternative Names	hKSR2; Kinase suppressor of Ras 2; KSR2;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.Ota T., Nat. Genet. 36:40-45(2004).Scherer S.E., Nature 440:346-351(2006).Channavajhala P.L., J. Biol. Chem. 278:47089-47097(2003).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human KSR2.
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Ota T., Nat. Genet. 36:40-45(2004). Scherer S.E., Nature 440:346-351(2006). Channavajhala P.L., J. Biol. Chem. 278:47089-47097(2003).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total KSR2 protein.
Subcellular Location	Cytoplasm, Membrane, Peripheral membrane protein

Uniprot	Q6VAB6
Database Links	HGNC:18610 OMIM:610737 KEGG:hsa:283455 STRING:9606.ENSP00000339952 UniGene:Hs.375836
Function	Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
Pathway	Ras signaling pathway
Protein Families	Protein kinase superfamily, TKL Ser/Thr protein kinase family
Tissue Specificity	Mainly expressed in brain and kidney.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559331	CSB-PA581207	100ul	$297		Add to Cart

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