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Home / Antibodies

KCNQ5 Antibody

SKU : BHA10558590

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA876430
Alternative Names	Potassium voltage-gated channel subfamily KQT member 5; Voltage-gated potassium channel subunit Kv7.5; Potassium channel subunit alpha KvLQT5; KQT-like 5;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M1 muscarinic receptors.Lerche C., J. Biol. Chem. 275:22395-22400(2000).Mungall A.J., Nature 425:805-811(2003).Schroeder B.C., J. Biol. Chem. 275:24089-24095(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human KCNQ5.
Involvement In Disease	Mental retardation, autosomal dominant 46 (MRD46)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M1 muscarinic receptors. Lerche C., J. Biol. Chem. 275:22395-22400(2000). Mungall A.J., Nature 425:805-811(2003). Schroeder B.C., J. Biol. Chem. 275:24089-24095(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total KCNQ5 protein.
Subcellular Location	Cell membrane, Multi-pass membrane protein

Uniprot	Q9NR82
Database Links	HGNC:6299 OMIM:607357 KEGG:hsa:56479 STRING:9606.ENSP00000345055 UniGene:Hs.445324
Function	Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. As the native M-channel, the potassium channel composed of KCNQ3 and KCNQ5 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1.
Protein Families	Potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.5/KCNQ5 sub-subfamily
Tissue Specificity	Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558590	CSB-PA876430	100ul	$297		Add to Cart

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