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Home / Antibodies

KCNQ4 Antibody

SKU : BHA10558589

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA288698
Alternative Names	Potassium voltage-gated channel subfamily KQT member 4; Voltage-gated potassium channel subunit Kv7.4; Potassium channel subunit alpha KvLQT4; KQT-like 4;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.Kubisch C., Cell 96:437-446(1999).Gregory S.G., Nature 441:315-321(2006).Selyanko A.A., J. Physiol. (Lond.) 522:349-355(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human KCNQ4.
Involvement In Disease	Deafness, autosomal dominant, 2A (DFNA2A)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors. Kubisch C., Cell 96:437-446(1999). Gregory S.G., Nature 441:315-321(2006). Selyanko A.A., J. Physiol. (Lond.) 522:349-355(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total KCNQ4 protein.
Subcellular Location	Basal cell membrane, Multi-pass membrane protein

Uniprot	P56696
Database Links	HGNC:6298 OMIM:600101 KEGG:hsa:9132 STRING:9606.ENSP00000262916 UniGene:Hs.473058
Function	Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
Protein Families	Potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.4/KCNQ4 sub-subfamily
Tissue Specificity	Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558589	CSB-PA288698	100ul	$297		Add to Cart

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