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Home / Primary Antibodies

KCNA5 Antibody

SKU : BHA10558585

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA074982
Alternative Names	Potassium voltage-gated channel subfamily A member 5; Voltage-gated potassium channel subunit Kv1.5; HK2; HPCN1;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.Tamkun M.M., FASEB J. 5:331-337(1991).Philipson L.H., Proc. Natl. Acad. Sci. U.S.A. 88:53-57(1991).Curran M.E., Genomics 12:729-737(1992).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human KCNA5.
Involvement In Disease	Atrial fibrillation, familial, 7 (ATFB7)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation. Tamkun M.M., FASEB J. 5:331-337(1991). Philipson L.H., Proc. Natl. Acad. Sci. U.S.A. 88:53-57(1991). Curran M.E., Genomics 12:729-737(1992).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total KCNA5 protein.
Subcellular Location	Cell membrane, Multi-pass membrane protein

Uniprot	P22460
Database Links	HGNC:6224 OMIM:176267 KEGG:hsa:3741 STRING:9606.ENSP00000252321 UniGene:Hs.150208
Function	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel
Protein Families	Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.5/KCNA5 sub-subfamily
Tissue Specificity	Pancreatic islets and insulinoma.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558585	CSB-PA074982	100ul	$297		Add to Cart

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