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Home / Primary Antibodies

KCNA1 Antibody

SKU : BHA10558584

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA220416
Alternative Names	HBK1; HUKI; KCNA1; potassium channel Kv1.1; potassium voltage-gated channel subfamily A member 1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.Chapman C.G., Brain Res. Mol. Brain Res. 82-74-83(2000).Gray A.T., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.Lesage F., FEBS Lett. 471:137-140(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human KCNA1.
Involvement In Disease	Episodic ataxia 1 (EA1); Myokymia isolated 1 (MK1)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Chapman C.G., Brain Res. Mol. Brain Res. 82-74-83(2000). Gray A.T., Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. Lesage F., FEBS Lett. 471:137-140(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total KCNA1 protein.
Subcellular Location	Cell membrane, Multi-pass membrane protein, Membrane, Cell projection, axon, Cytoplasmic vesicle, Perikaryon, Endoplasmic reticulum, Cell projection, dendrite, Cell junction, Cell junction, synapse, Cell junction, synapse, presynaptic cell membrane

Uniprot	Q09470
Database Links	HGNC:6218 OMIM:160120 KEGG:hsa:3736 STRING:9606.ENSP00000371985 UniGene:Hs.416139
Function	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney
Protein Families	Potassium channel family, A (Shaker) (TC 1.A.1.2) subfamily, Kv1.1/KCNA1 sub-subfamily
Tissue Specificity	Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297). Detected in the islet of Langerhans (PubMed:21483673).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558584	CSB-PA220416	100ul	$297		Add to Cart

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