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Home / Antibodies

KAT7 Antibody

SKU : BHA10559255

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA980473
Alternative Names	EC 2.3.1.48; HBO1; HBOA; MYST histone acetyltransferase 2;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription.Iizuka M., J. Biol. Chem. 274:23027-23034(1999).Sharma M., J. Biol. Chem. 275:35200-35208(2000).Olsen J.V., Cell 127:635-648(2006).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human MYST2.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. Iizuka M., J. Biol. Chem. 274:23027-23034(1999). Sharma M., J. Biol. Chem. 275:35200-35208(2000). Olsen J.V., Cell 127:635-648(2006).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total MYST2 protein.
Subcellular Location	Nucleus, nucleoplasm, Cytoplasm, cytosol, Nucleus

Uniprot	O95251
Database Links	HGNC:17016 OMIM:609880 KEGG:hsa:11143 STRING:9606.ENSP00000259021 UniGene:Hs.21907
Function	Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1
Protein Families	MYST (SAS/MOZ) family
Tissue Specificity	Ubiquitously expressed, with highest levels in testis.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559255	CSB-PA980473	100ul	$297		Add to Cart

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