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Home / Antibodies

JUN (Ab-63) Antibody

SKU : BHA10557663

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA570612
Alternative Names	Activator protein 1; AH119; AP-1; AP1; c-Jun
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.Wei W, et al. (2005). Cancer Cell. 8(1): 25-33.Sevilla A, et al. (2004). Oncogene.23(55): 8950-8958.Li L, et al. (2004). J Biol Chem.279(6): 4058-4065.Hurd C, et al. (2002). Oncogene.21(14): 2154-2160.
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human c-Jun around the phosphorylation site of Serine 63.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Wei W, et al. (2005). Cancer Cell. 8(1): 25-33. Sevilla A, et al. (2004). Oncogene.23(55): 8950-8958. Li L, et al. (2004). J Biol Chem.279(6): 4058-4065. Hurd C, et al. (2002). Oncogene.21(14): 2154-2160.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of c-Jun protein around Serine 63.
Subcellular Location	Nucleus

Uniprot	P05412
Gene Id	3725
Database Links	HGNC:6204 OMIM:165160 KEGG:hsa:3725 STRING:9606.ENSP00000360266 UniGene:Hs.696684
Function	Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells
Pathway	cAMP signaling pathway ErbB signaling pathway Estrogen signaling pathway MAPK signaling pathway Wnt signaling pathway Focal adhesion TNF signaling pathway Apoptosis B cell receptor signaling pathway IL-17 signaling pathway NOD-like receptor signaling pathway Osteoclast differentiation T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Toll-like receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications Neurotrophin signaling pathway
Protein Families	BZIP family, Jun subfamily
Weight	35,676 Da

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557663	CSB-PA570612	100ul	$297		Add to Cart

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