Tyrosine-protein kinase JAK2 is a non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. (UniProt)
Formulation
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host
Rabbit
Immunogen Region
A synthetic peptide specific to human JAK2 was used as the immunogen for the JAK2 antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
JAK2
Uniprot
O60674
Clone No
COG-10
Format
Purified
Purification
Affinity purified
Storage
Store the JAK2 antibody at -20°C.
Applications
IF/ICC, WB
Dilution
Western blot: 1:500-1:2000,Immunofluorescence/Immunocytochemistry: 1:50-1:200