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Home / Primary Antibodies

ITGB3 (Ab-785) Antibody

SKU : BHA10557485

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA226353
Alternative Names	CD61 antigen; GP3A; GPIIIa; ITB3; Platelet membrane glycoprotein IIIa
Categories	Primary Antibodies
Clonality	polyclonal
Description	The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with a and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct a subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-a2B or the Itg-Beta3 subunit Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397(Pt 3): 437
Host	Rabbit
Immunogen	Peptide sequence around aa.783~787 (I-T-Y-R-G) derived from Human Integrin B3/ITGB3.
Involvement In Disease	Glanzmann thrombasthenia (GT); Bleeding disorder, platelet-type 16 (BDPLT16)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with a and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct a subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-a2B or the Itg-Beta3 subunit Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397(Pt 3): 437
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total Integrin b3 protein.
Subcellular Location	Cell membrane, Single-pass type I membrane protein, Cell projection, lamellipodium membrane, Cell junction, focal adhesion

Uniprot	P05106
Database Links	HGNC:6156 OMIM:173470 KEGG:hsa:3690 STRING:9606.ENSP00000262017 UniGene:Hs.218040
Function	Integrin alpha-V/beta-3 (ITGAV
Pathway	PI3K-Akt signaling pathway Focal adhesion Regulation of actin cytoskeleton Hematopoietic cell lineage Osteoclast differentiation Rap1 signaling pathway
Protein Families	Integrin beta chain family
Tissue Specificity	Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557485	CSB-PA226353	100ul	$297		Add to Cart

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