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ITGA4 Antibody

SKU : BHA10557564

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA977888
Alternative Names	IA4; MGC90518; ITGA4
Categories	Primary Antibodies
Clonality	polyclonal
Description	Integrins a-4/beta-1 (VLA-4) and a-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin a-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin a-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.Iida J., Meijne A.M.L., Oegema T.R. Jr. J. Biol. Chem. 273:5955-5962(1998) Liu S., Thomas S.M., Woodside D.G., Rose D.M. Nature 402:676-681(1999), Integrins a-4/beta-1 (VLA-4) and a-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin a-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin a-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.Iida J., Meijne A.M.L., Oegema T.R. Jr. J. Biol. Chem. 273:5955-5962(1998) Liu S., Thomas S.M., Woodside D.G., Rose D.M. Nature 402:676-681(1999)
Host	Rabbit
Immunogen	Peptide sequence around aa.1024~1028(Y-I-N-S-K) derived from Human LPAM-1(Integrin a4, CD49d)., Peptide sequence around aa.1024~1028(Y-I-N-S-K) derived from Human LPAM-1(Integrin a4, CD49d).
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Integrins a-4/beta-1 (VLA-4) and a-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin a-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin a-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Iida J., Meijne A.M.L., Oegema T.R. Jr. J. Biol. Chem. 273:5955-5962(1998) Liu S., Thomas S.M., Woodside D.G., Rose D.M. Nature 402:676-681(1999)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total LPAM-1(Integrin a4, CD49d) protein.
Subcellular Location	Membrane, Single-pass type I membrane protein, Membrane, Single-pass type I membrane protein

Uniprot	P13612
Database Links	HGNC:6140 OMIM:192975 KEGG:hsa:3676 STRING:9606.ENSP00000380227 UniGene:Hs.440955
Function	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4
Pathway	PI3K-Akt signaling pathway Focal adhesion Regulation of actin cytoskeleton Hematopoietic cell lineage Leukocyte transendothelial migration
Protein Families	Integrin alpha chain family

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557564	CSB-PA977888	100ul	$297		Add to Cart

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