Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.Rosati O., Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.Muzio M., Science 278:1612-1615(1997).Wesche H., J. Biol. Chem. 274:19403-19410(1999).
Host
Rabbit
Immunogen
Synthesized peptide derived from Internal of Human IRAK2.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Rosati O., Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases. Muzio M., Science 278:1612-1615(1997). Wesche H., J. Biol. Chem. 274:19403-19410(1999).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total IRAK2 protein.
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Pathway
Neurotrophin signaling pathway
Protein Families
Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
Tissue Specificity
Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.