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Home / Primary Antibodies

Integrin beta 4 Antibody / ITGB4 / CD104 (V2163SAF)

SKU : BHA17123513

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NSJ Bioreagents

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Mfr.No.	V2163SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	This antibody recognizes a protein of 205kDa, which is identified as integrin beta 4 (ITGB4) and CD104. Its epitope is localized in the extracellular domain of integrin beta 4 protein. Integrins are heterodimers comprised of a and b subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of a and b polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	The human squamous cell carcinoma line (UM-SCC1) was used as the immunogen for this Integrin beta 4 / CD104 antibody.
Isotype	Mouse IgG2a, kappa
Species Reactivity	Human
Note	The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the Integrin Beta 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	Blocking, FACS, IF
Description	Biological Blockade (Partially blocks laminin binding) (order BSA/sodium azide-free format),Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17123513	V2163SAF-100UG	100 ug	$499		Add to Cart

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