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Home / Antibodies

Insulin Receptor alpha Antibody (V8071)

SKU : BHA17117485

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NSJ Bioreagents

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Mfr.No.	V8071, V8071-20UG, V8071-100UG
Clonality	Monoclonal
Description	The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.
Formulation	0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Host	Mouse
Immunogen Region	A recombinant fragment from the extracellular domain of human Insulin Receptor alpha was used as the immunogen for this Insulin Receptor alpha antibody.
Isotype	IgG1,kappa
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Uniprot	P06213
Clone No	INSR/1661

Concentration	0.2 mg/ml
Format	Purified
Purification	Protein G affinity chromatography
Storage	Store the Insulin Receptor alpha antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Applications	ELISA
Dilution	ELISA (order BSA-free format for coating)

Product Manual	Data Sheet

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17117485-1	V8071-20UG	20ug	$219		Add to Cart
BHA17117485-2	V8071-100UG	100ug	$499		Add to Cart

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