After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. (provided by RefSeq).
Formulation
In ascites with 0.09% sodium azide
Host
Mouse
Immunogen Region
A portion of amino acids 35-64 from the human protein was used as the immunogen for this Insulin antibody.
Isotype
IgM
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Uniprot
P01308
Clone No
396CT20.4.4
Format
Ascites
Purification
Ascites
Storage
Aliquot the Insulin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.