CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudo-autosomal region on chromosomes X or Y.
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
A portion of amino acids 26-171 was used as the immunogen for the IL3RA antibody.
Isotype
Mouse IgG2a, kappa
Species Reactivity
Human
Note
Optimal dilution of the IL3RA antibody should be determined by the researcher.
Uniprot
P26951
Format
Purified
Purity
Protein A/G affinity
Storage
Aliquot the IL3RA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Applications
ELISA
Description
ELISA: 2-4ug/ml (order BSA-free format for coating)