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IL17RC Antibody

SKU : BHA10558824

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA185992
Alternative Names	Interleukin-17 receptor C; IL-17 receptor C; IL-17RC; Interleukin-17 receptor-like protein; IL-17RL
Categories	Primary Antibodies
Clonality	polyclonal
Description	This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.Gray A.M., Genome Res. 13:2265-2270(2003).Gibbs R.A., Nature 440:1194-1198(2006).Henzel W.J., Protein Sci. 13:2819-2824(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human IL17RC.
Involvement In Disease	Candidiasis, familial, 9 (CANDF9)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. Gray A.M., Genome Res. 13:2265-2270(2003). Gibbs R.A., Nature 440:1194-1198(2006). Henzel W.J., Protein Sci. 13:2819-2824(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total IL17RC protein.
Subcellular Location	Cell membrane, Single-pass type I membrane protein

Uniprot	Q8NAC3
Database Links	HGNC:18358 OMIM:610925 KEGG:hsa:84818 STRING:9606.ENSP00000295981 UniGene:Hs.129959
Function	Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA
Pathway	IL-17 signaling pathway
Tissue Specificity	Expressed in prostate, skeletal muscle, kidney and placenta (at protein level) (PubMed:11706037). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate (PubMed:11706037). Also detected in thyroid, trac

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558824	CSB-PA185992	100ul	$297		Add to Cart

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