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Home / Antibodies

IL11RA Antibody

SKU : BHA10558822

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA043792
Alternative Names	Interleukin-11 receptor subunit alpha; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA
Categories	Primary Antibodies
Clonality	polyclonal
Description	Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.Cherel M., Blood 86:2534-2540(1995).Van Leuven F., Genomics 31:65-70(1996).Kalnine N., Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Synthesized peptide derived from C-terminal of Human IL11RA.
Involvement In Disease	Craniosynostosis and dental anomalies (CRSDA)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number. Cherel M., Blood 86:2534-2540(1995). Van Leuven F., Genomics 31:65-70(1996). Kalnine N., Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total IL11RA protein.
Subcellular Location	Membrane, Single-pass type I membrane protein

Uniprot	Q14626
Database Links	HGNC:5967 OMIM:600939 KEGG:hsa:3590 STRING:9606.ENSP00000326500 UniGene:Hs.591088
Function	Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.
Pathway	Jak-STAT signaling pathway Hematopoietic cell lineage
Protein Families	Type I cytokine receptor family, Type 3 subfamily
Tissue Specificity	Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malig

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558822	CSB-PA043792	100ul	$297		Add to Cart

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