Inhibitor of nuclear factor kappa-B kinase subunit alpha, also known as conserved helix-loop-helix ubiquitous kinase (CHUK) or IKBKA, is a protein kinase that in humans is encoded by the CHUK gene. It is mapped to 10q24.31. This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. IKK alpha is part of the IkB kinase complex that plays an important role in regulating the NF-kB transcription factor. IKK alpha also has many additional cellular targets, and is thought to function independently of the NF-kB pathway to regulate epidermal differentiation.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Human partial recombinant protein (AA 411-745) was used as the immunogen for this IKK alpha antibody.
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Gene Id
1147
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the IKK alpha antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.