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Home / Antibodies

IKBKG (Ab-85) Antibody

SKU : BHA10559119

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA177488
Alternative Names	FIP-3; FIP3; I-kappa-B kinase gamma; IKBKG; IKK-gamma
Categories	Primary Antibodies
Clonality	polyclonal
Description	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999).Jin D.-Y., J. Biomed. Sci. 6:115-120(1999).Rothwarf D.M., Nature 395:297-300(1998).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human IKK-γ around the phosphorylation site of serine 85 (Q-A-S(p)-Q-R).
Involvement In Disease	Ectodermal dysplasia, anhidrotic, with immunodeficiency X-linked (EDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis and lymphedema (OLEDAID); Immunodeficiency, NEMO-related, without anhidrotic ectodermal dysplasia (NEMOID); Immunodeficiency 33 (IMD33); Recurrent isolated invasive pneumococcal disease 2 (IPD2); Incontinentia pigmenti (IP)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999). Jin D.-Y., J. Biomed. Sci. 6:115-120(1999). Rothwarf D.M., Nature 395:297-300(1998).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total IKK-γ protein.
Subcellular Location	Cytoplasm, Nucleus

Uniprot	Q9Y6K9
Database Links	HGNC:5961 OMIM:300248 KEGG:hsa:8517 STRING:9606.ENSP00000358622 UniGene:Hs.43505
Function	Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
Pathway	Chemokine signaling pathway MAPK signaling pathway PI3K-Akt signaling pathway NF-kappa B signaling pathway TNF signaling pathway Apoptosis Ras signaling pathway B cell receptor signaling pathway IL-17 signaling pathway NOD-like receptor signaling pathway Osteoclast differentiation T cell receptor signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation Toll-like receptor signaling pathway Adipocytokine signaling pathway
Tissue Specificity	Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559119	CSB-PA177488	100ul	$297		Add to Cart

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