DNA-binding protein inhibitor ID-4; Inhibitor of DNA binding 4; ID4;
Categories
Primary Antibodies
Clonality
polyclonal
Description
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.Rigolet M., DNA Res. 5:309-313(1998).Pagliuca A., Genomics 27:200-203(1995).Mungall A.J., Nature 425:805-811(2003).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human ID4.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding.
Rigolet M., DNA Res. 5:309-313(1998). Pagliuca A., Genomics 27:200-203(1995). Mungall A.J., Nature 425:805-811(2003).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total ID4 protein.
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).
Pathway
TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.