Recognizes an 85-115kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1). It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1). This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. ICAM-1 may also be related to progression and metastasis of tumors.
Formulation
1 mg/ml in 1X PBS; BSA free, sodium azide free
Host
Mouse
Immunogen Region
A recombinant protein fragment was used as the immunogen for the ICAM1 antibody.
Isotype
Mouse IgG
Species Reactivity
Human
Note
Optimal dilution of the ICAM1 antibody should be determined by the researcher.
Uniprot
P05362
Format
Purified
Purity
Protein A/G affinity
Storage
Aliquot the ICAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.