The heat-shock proteins(HSPs) belong to a larger group of polypeptides, the stress proteins, that are induced in various combinations in response to environmental challenges and developmental transitions. Heat-shock 27-kD protein1also knows as HSPB. Synthesis of the small(27-kD) HSP has been shown to be correlated with the acquisition of thermotolerance. HSP27 gene is mapped to 7q11.23. Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.
Formulation
0.5mg/ml with 1% BSA and 0.01% sodium azide if reconstituted with 0.2ml sterile 1XPBS
Host
Mouse
Immunogen Region
Partially purified inhibitor of actin polymerization (IAP) protein from turkey gizzard smooth muscle was used as the immunogen for this HSP25 antibody.
Isotype
IgG1
Predicted Reactivity
Human, rat, mouse, rabbit
Reactivity
Human, Rat, Mouse, Rabbit
Recombinant
No
Gene Id
3315
Clone No
IAP-9
Format
Ascites
Purification
Ascites
Storage
After reconstitution, the HSP25 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.