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Home / Antibodies

HSD17B10 Antibody

SKU : BHA10557547

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA695225
Alternative Names	ABAD; CAMR; HCD2; MHBD; HADH2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Holzmann J., Frank P., Loeffler E., Bennett K.L., Gerner C., Rossmanith W. Cell 135:462-474(2008)
Host	Rabbit
Immunogen	Peptide sequence around aa.253~257(L-D-G-A-I)derived from Human ERAB.
Involvement In Disease	HDS10 mitochondrial disease (HSD10MD); Mental retardation, X-linked 17 (MRX17)
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Holzmann J., Frank P., Loeffler E., Bennett K.L., Gerner C., Rossmanith W. Cell 135:462-474(2008)
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous level of total ERAB protein.
Subcellular Location	Mitochondrion

Uniprot	Q99714
Database Links	HGNC:4800 OMIM:300256 KEGG:hsa:3028 STRING:9606.ENSP00000168216 UniGene:Hs.171280
Function	Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone
Protein Families	Short-chain dehydrogenases/reductases (SDR) family
Tissue Specificity	Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD.

Buffer	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:1000

Tested Application

ELISA,WB;WB:1:500-1:1000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557547	CSB-PA695225	100ul	$297		Add to Cart

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