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Home / Primary Antibodies

HMGB1 Antibody

SKU : BHA10557794

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA049959
Alternative Names	HMG-1; HMG1; High mobility group protein 1; SBP-1; amphoterin
Categories	Primary Antibodies
Clonality	polyclonal
Description	DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells By similarity.Wen L., Nucleic Acids Res. 17:1197-1214(1989).Ferrari S., Genomics 35:367-371(1996).Rasmussen R.K., Electrophoresis 18:588-598(1997).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human HMGB1.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells By similarity. Wen L., Nucleic Acids Res. 17:1197-1214(1989). Ferrari S., Genomics 35:367-371(1996). Rasmussen R.K., Electrophoresis 18:588-598(1997).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total HMGB1 protein.
Subcellular Location	Nucleus, Chromosome, Cytoplasm, Secreted, Cell membrane, Peripheral membrane protein, Extracellular side, Endosome, Endoplasmic reticulum-Golgi intermediate compartment

Uniprot	P09429
Database Links	HGNC:4983 OMIM:163905 KEGG:hsa:3146 STRING:9606.ENSP00000343040 UniGene:Hs.434102
Function	Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury
Pathway	Autophagy Necroptosis DNA repair pathway
Protein Families	HMGB family
Tissue Specificity	Ubiquituous. Expressed in platelets (PubMed:11154118).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557794	CSB-PA049959	100ul	$297		Add to Cart

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