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Home / Primary Antibodies

HLA-B Antibody (MHC Class I) (V8848SAF)

SKU : BHA17122900

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NSJ Bioreagents

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Mfr.No.	V8848SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	Normal human peripheral blood lymphocytes were used as the immunogen for the HLA-B antibody.
Isotype	Mouse IgG, kappa
Species Reactivity	Human
Note	Optimal dilution of the HLA-B antibody should be determined by the researcher.

Uniprot	P01889

Format	Purified
Purity	Protein A/G affinity
Storage	Aliquot the HLA-B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	FACS, IF
Description	Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml

Product Manual	Datasheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17122900	V8848SAF-100UG	100ug	$499		Add to Cart

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