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Home / Antibodies

Histone H2AX Antibody

SKU : BHA10559273

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA833019
Alternative Names	H2A.X; H2AFX; H2a/x; HIST5-2AX; Histone H2A.X
Categories	Primary Antibodies
Clonality	polyclonal
Description	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.The MGC Project Team; Genome Res. 14:2121-2127(2004).Rogakou E.P., J. Biol. Chem. 273:5858-5868(1998).Rogakou E.P., J. Biol. Chem. 275:9390-9395(2000).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human Histone H2AX.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. The MGC Project Team; Genome Res. 14:2121-2127(2004). Rogakou E.P., J. Biol. Chem. 273:5858-5868(1998). Rogakou E.P., J. Biol. Chem. 275:9390-9395(2000).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total Histone H2AX protein.
Subcellular Location	Nucleus, Chromosome

Uniprot	P16104
Database Links	HGNC:4739 OMIM:601772 KEGG:hsa:3014 STRING:9606.ENSP00000364310 UniGene:Hs.477879
Function	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Pathway	Necroptosis
Protein Families	Histone H2A family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559273	CSB-PA833019	100ul	$297		Add to Cart

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