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Home / Primary Antibodies / Monoclonal Antibodies

HCN2 Antibody, Clone S71 - SMC-305

BHA11902538
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Email
[email protected]
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Swissprot Q9JKA9
Accession Number NP_446136.1
Gene Id 114244
Target HCN2
Clone No S71
Research Area cardiovascular System, Ion Channels, Cyclic Nucleotide-Gated Ion Channels, Heart, Neuroscience
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background Hyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) is an integral membrane protein that helps establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). Ion channels are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain (3).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~95kDa. No cross-reactivity against HCN1.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications AM, IHC, IP, WB, ICC/IF
Description WB ; IHC ; ICC ; IF ; IP ; AM
Dilution WB (1:1000), IHC (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.:Sunderland, MA USA.

2. www.iochannels.org

3. Zong X., et al. (2005) J Biol Chem. 280(40): 34224-34232
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11902538-1 SMC-305D Unconjugated 100 ug $330
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BHA11902538-2 SMC-305D-A390 ATTO 390 100 ug $384
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BHA11902538-3 SMC-305D-A488 ATTO 488 100 ug $383
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BHA11902538-4 SMC-305D-A594 ATTO 594 100 ug $383
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BHA11902538-5 SMC-305D-ALP Alkaline Phosphatase 100 ug $376
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BHA11902538-6 SMC-305D-APC APC 100 ug $382
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BHA11902538-7 SMC-305D-BI Biotin 100 ug $378
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BHA11902538-8 SMC-305D-FITC FITC 100 ug $374
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BHA11902538-9 SMC-305D-HRP HRP 100 ug $370
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BHA11902538-10 SMC-305D-PCP PerCP 100 ug $382
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BHA11902538-11 SMC-305D-RPE RPE 100 ug $380
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BHA11902538-12 SMC-305S Unconjugated 12 ug $44
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