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Home / Primary Antibodies

GTF2IRD1 Antibody

SKU : BHA10558052

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA911147
Alternative Names	CREAM1; G2D1; GT2D1; GTF2I repeat domain containing protein 1; GTF2IRD1
Categories	Primary Antibodies
Clonality	polyclonal
Description	May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 By similarity.Yan X., Biochem. J. 345:749-757(2000).Hillier L.W., Nature 424:157-164(2003).Tussie-Luna M.I., Proc. Natl. Acad. Sci. U.S.A. 98:7789-7794(2001).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human GTF2IRD1.
Involvement In Disease	GTF2IRD1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of GTF2IRD1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 By similarity. Yan X., Biochem. J. 345:749-757(2000). Hillier L.W., Nature 424:157-164(2003). Tussie-Luna M.I., Proc. Natl. Acad. Sci. U.S.A. 98:7789-7794(2001).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total GTF2IRD1 protein.
Subcellular Location	Nucleus

Uniprot	Q9UHL9
Database Links	HGNC:4661 OMIM:604318 KEGG:hsa:9569 STRING:9606.ENSP00000397566 UniGene:Hs.647056
Function	May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity).
Pathway	cGMP-PKG signaling pathway
Protein Families	TFII-I family
Tissue Specificity	Highly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558052	CSB-PA911147	100ul	$297		Add to Cart

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