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GTF2H2 Antibody

SKU : BHA10557914

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA714270
Alternative Names	TFIIH basal transcription factor complex p44 subunit; Basic transcription factor 2 44 kDa subunit; BTF2-p44; General transcription factor IIH polypeptide 2; GTF2H2
Categories	Primary Antibodies
Clonality	polyclonal
Description	Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.Humbert S., EMBO J. 13:2393-2398(1994).The MGC Project Team, Genome Res. 14:2121-2127(2004).van der Steege G., Eur. J. Hum. Genet. 3:87-95(1995).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human TF2H2.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. Humbert S., EMBO J. 13:2393-2398(1994). The MGC Project Team, Genome Res. 14:2121-2127(2004). van der Steege G., Eur. J. Hum. Genet. 3:87-95(1995).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total TF2H2 protein.
Subcellular Location	Nucleus

Uniprot	Q13888
Database Links	HGNC:4656 OMIM:601748 KEGG:hsa:2966 STRING:9606.ENSP00000274400 UniGene:Hs.191356
Function	Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
Pathway	DNA repair pathway
Protein Families	GTF2H2 family
Tissue Specificity	Widely expressed, with higher expression in skeletal muscle.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557914	CSB-PA714270	100ul	$297		Add to Cart

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