Belongs to the gasdermin family.Watabe K., Jpn. J. Cancer Res. 92:140-151(2001).Nusbaum C., Nature 439:331-335(2006).The MGC Project Team, Genome Res. 14:2121-2127(2004).
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human GSDMC.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Belongs to the gasdermin family.
Watabe K., Jpn. J. Cancer Res. 92:140-151(2001). Nusbaum C., Nature 439:331-335(2006). The MGC Project Team, Genome Res. 14:2121-2127(2004).
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total GSDMC protein.
The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores
Protein Families
Gasdermin family
Tissue Specificity
Expressed mainly in trachea and spleen (PubMed:11223543). In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium (PubMed:19051310).
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.