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Home / Primary Antibodies / Monoclonal Antibodies

GRP78 Antibody, Clone 6H4-2G7 - SMC-196

BHA11901510
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+1 866.986.9598
Email
[email protected]
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Swissprot P20029
Accession Number NP_001156906.1
Gene Id 14828
Target GRP78
Clone No 6H4-2G7
Research Area Cancer, Heat Shock, Cell Signaling, Chaperone Proteins, Organelle Markers, Protein Trafficking
Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration 1 mg/ml
Dilutions WB (1:2000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Purification Protein G Purified
Scientific Background GRP78 is a ubiquitously expressed, 78-kDa glucose- regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1).
GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Lou et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3).
In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer's patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).
Shipping Temperature Blue Ice or 4°C
Specificity Detects ~78kDa.
Storage -20ºC
Storage Buffer PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Storage Temperature -20°C
Applications ELISA, WB, ICC/IF
Description WB ; ICC ; IF ; ELISA
Dilution WB (1:2000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
Product Manual SDS
SDS
Reference 1. Cho S., et al. (2007) Mol Cell Biol. 27(1): 368-83.

2. Yang Y., et al. (1998) J Biol Chem 273: 25552-25555.

3. Luo S., et al (2006) 26 (15): 5688-97.

4. Yu Z., et al. (1999) Exp Neurol. 15: 302-314.

5. Koomagi R., et al. (1999) Anticancer Res. 19:4333-4336.

6. Laquerre S., et al. (1998) J. Virology 72: 4940-4949.

7. Dong D., et al. (2005) Cancer Res 65(13): 5785-91.
Combination SKU Supplier No. Conjugate Size Your price Quantity
BHA11901510-1 SMC-196D Unconjugated 100 ug $295
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BHA11901510-2 SMC-196D-A390 ATTO 390 100 ug $349
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BHA11901510-3 SMC-196D-A488 ATTO 488 100 ug $348
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BHA11901510-4 SMC-196D-A594 ATTO 594 100 ug $348
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BHA11901510-5 SMC-196D-ALP Alkaline Phosphatase 100 ug $341
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BHA11901510-6 SMC-196D-APC APC 100 ug $347
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BHA11901510-7 SMC-196D-BI Biotin 100 ug $343
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BHA11901510-8 SMC-196D-FITC FITC 100 ug $339
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BHA11901510-9 SMC-196D-HRP HRP 100 ug $334
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BHA11901510-10 SMC-196D-PCP PerCP 100 ug $347
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BHA11901510-11 SMC-196D-RPE RPE 100 ug $344
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BHA11901510-12 SMC-196S Unconjugated 12 ug $44
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