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Home / Primary Antibodies

GRK6 Antibody

SKU : BHA10559298

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA213352
Alternative Names	EC 2.7.11.16; G-protein-coupled receptor kinase 6; GPRK6; kinase GRK6;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis By similarity. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).Benovic J.L., J. Biol. Chem. 268:19521-19527(1993).Haribabu B., Proc. Natl. Acad. Sci. U.S.A. 90:9398-9402(1993).Stoffel R.H., J. Biol. Chem. 269:27791-27794(1994).
Host	Rabbit
Immunogen	Synthesized peptide derived from N-terminal of Human GRK6.
Raised In	Rabbit
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Relevance	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis By similarity. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). Benovic J.L., J. Biol. Chem. 268:19521-19527(1993). Haribabu B., Proc. Natl. Acad. Sci. U.S.A. 90:9398-9402(1993). Stoffel R.H., J. Biol. Chem. 269:27791-27794(1994).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total GRK6 protein.
Subcellular Location	Membrane, Lipid-anchor

Uniprot	P43250
Database Links	HGNC:4545 OMIM:600869 KEGG:hsa:2870 STRING:9606.ENSP00000433511 UniGene:Hs.235116
Function	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor
Pathway	Chemokine signaling pathway Endocytosis
Protein Families	Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
Tissue Specificity	Widely expressed.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB, IF

Description

ELISA ; WB ; IF, WB ; ELISA ; IF

Dilution

WB	1:500-1:3000
IF	1:100-1:500

Tested Application

ELISA,WB,IF;WB:1:500-1:3000,IF:1:100-1:500

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10559298	CSB-PA213352	100ul	$297		Add to Cart

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