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Home / Antibodies

GRIN2B (Ab-1303) Antibody

SKU : BHA10557709

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA149419
Alternative Names	Glutamate [NMDA] receptor subunit epsilon 2 precursor; GRIN2B; hNR3; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subtype 2B
Categories	Primary Antibodies
Clonality	polyclonal
Description	NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death By similarity.Lasky L.A., J. Biol. Chem. 275:21477-21485(2000).Mandich P., Neurosci. Lett. 239:49-53(1997).Ajmar F., Genomics 22:216-218(1994).
Host	Rabbit
Immunogen	Synthesized non-phosphopeptide derived from Human GRIN2B around the phosphorylation site of serine 1303 (Q-H-S(p)-Y-D).
Involvement In Disease	Mental retardation, autosomal dominant 6, with or without seizures (MRD6); Epileptic encephalopathy, early infantile, 27 (EIEE27)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death By similarity. Lasky L.A., J. Biol. Chem. 275:21477-21485(2000). Mandich P., Neurosci. Lett. 239:49-53(1997). Ajmar F., Genomics 22:216-218(1994).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total GRIN2B protein.
Subcellular Location	Cell membrane, Multi-pass membrane protein, Cell junction, synapse, postsynaptic cell membrane, Multi-pass membrane protein

Uniprot	Q13224
Database Links	HGNC:4586 OMIM:138252 KEGG:hsa:2904 STRING:9606.ENSP00000279593 UniGene:Hs.504844
Function	Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+)
Pathway	cAMP signaling pathway Ras signaling pathway Rap1 signaling pathway Glutamatergic synapse
Protein Families	Glutamate-gated ion channel (TC 1.A.10.1) family, NR2B/GRIN2B subfamily
Tissue Specificity	Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557709	CSB-PA149419	100ul	$297		Add to Cart

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