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Home / Primary Antibodies

GRIA2 (Ab-880) Antibody

BHA10557488
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Contact us to order
Tel
+1 866.986.9598
Email
[email protected]
Get a Quote
Ask Merchant
Request More Infos
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Uniprot P42262
Database Links

HGNC:4572

OMIM:138247

KEGG:hsa:2891

STRING:9606.ENSP00000264426

UniGene:Hs.32763
Function Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity).
Pathway cAMP signaling pathway Glutamatergic synapse
Protein Families Glutamate-gated ion channel (TC 1.A.10.1) family, GRIA2 subfamily
Buffer Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format liquid
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Purity Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Applications ELISA, WB
Description ELISA ; WB, WB ; ELISA
Dilution

WB1:500-1:1000
Tested Application ELISA,WB;WB:1:500-1:1000
Datasheet
ELISA Protocol
Western Blotting(WB) Protocol
SKU Supplier No. Size Your price Quantity
BHA10557488 CSB-PA799322 100ul $297
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