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GPR68 Antibody

SKU : BHA10557934

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA225320
Alternative Names	Sphingosylphosphorylcholine receptor; Ovarian cancer G-protein coupled receptor 1; OGR-1; G-protein coupled receptor 68; GPR12A
Categories	Primary Antibodies
Clonality	polyclonal
Description	Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer By similarity.An S., FEBS Lett. 375:121-124(1995).Xu Y., Genomics 35:397-402(1996).King M.M., Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human SPR1.
Involvement In Disease	Amelogenesis imperfecta, hypomaturation type, 2A6 (AI2A6)
Raised In	Rabbit
Reactivity	Human, Mouse
Regulatory	RUO
Relevance	Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca2+ mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer By similarity. An S., FEBS Lett. 375:121-124(1995). Xu Y., Genomics 35:397-402(1996). King M.M., Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total SPR1 protein.
Subcellular Location	Cell membrane, Multi-pass membrane protein

Uniprot	Q15743
Database Links	HGNC:4519 OMIM:601404 KEGG:hsa:8111 STRING:9606.ENSP00000434045 UniGene:Hs.8882
Function	Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer (By similarity).
Protein Families	G-protein coupled receptor 1 family
Tissue Specificity	Found at low level in a wide range of tissues, but significantly expressed in lung, kidney, bone and nervous system.

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10557934	CSB-PA225320	100ul	$297		Add to Cart

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