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Home / Primary Antibodies

GNL3L Antibody

SKU : BHA10558441

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA106099
Alternative Names	guanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein;
Categories	Primary Antibodies
Clonality	polyclonal
Description	Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.Ota T., Nat. Genet. 36:40-45(2004).Ross M.T., Nature 434:325-337(2005).The MGC Project Team; Genome Res. 14-2121-2127(2004).
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human GNL3L.
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. Ota T., Nat. Genet. 36:40-45(2004). Ross M.T., Nature 434:325-337(2005). The MGC Project Team; Genome Res. 14-2121-2127(2004).
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total GNL3L protein.
Subcellular Location	Nucleus, nucleolus

Uniprot	Q9NVN8
Database Links	HGNC:25553 OMIM:300873 KEGG:hsa:54552 STRING:9606.ENSP00000338573 UniGene:Hs.654677
Function	Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.
Protein Families	TRAFAC class YlqF/YawG GTPase family

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558441	CSB-PA106099	100ul	$297		Add to Cart

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