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Home / Antibodies

GLB1 Antibody

SKU : BHA10558274

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CUSABIO TECHONOLOGY LLC

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Mfr.No.	CSB-PA146106
Alternative Names	Beta-galactosidase; EC=3.2.1.23; Acid beta-galactosidase; Lactase; Elastin receptor 1
Categories	Primary Antibodies
Clonality	polyclonal
Description	Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. soform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.Oshima A., Biochem. Biophys. Res. Commun. 157:238-244(1988) [PubMed: 3143362].Morreau H., J. Biol. Chem. 264:20655-20663(1989) [PubMed: 2511208].Yamamoto Y., DNA Cell Biol. 9:119-127(1990) [PubMed: 2111707].
Host	Rabbit
Immunogen	Synthesized peptide derived from internal of Human GLB1.
Involvement In Disease	GM1-gangliosidosis 1 (GM1G1); GM1-gangliosidosis 2 (GM1G2); GM1-gangliosidosis 3 (GM1G3); Mucopolysaccharidosis 4B (MPS4B)
Raised In	Rabbit
Reactivity	Human
Regulatory	RUO
Relevance	Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. soform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. Oshima A., Biochem. Biophys. Res. Commun. 157:238-244(1988) [PubMed: 3143362]. Morreau H., J. Biol. Chem. 264:20655-20663(1989) [PubMed: 2511208]. Yamamoto Y., DNA Cell Biol. 9:119-127(1990) [PubMed: 2111707].
Species	Homo Sapiens (Human)
Specificity	The antibody detects endogenous levels of total GLB1 protein.
Subcellular Location	Isoform 1: Lysosome, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm, perinuclear region

Uniprot	P16278
Database Links	HGNC:4298 OMIM:230500 KEGG:hsa:2720 STRING:9606.ENSP00000306920 UniGene:Hs.443031
Function	Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.; FUNCTION
Protein Families	Glycosyl hydrolase 35 family
Tissue Specificity	Detected in placenta (at protein level) (PubMed:8383699). Detected in fibroblasts and testis (PubMed:2511208).

Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format	liquid
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Applications

ELISA, WB

Description

ELISA ; WB, WB ; ELISA

Dilution

WB	1:500-1:3000

Tested Application

ELISA,WB;WB:1:500-1:3000

Datasheet
ELISA Protocol
Western Blotting(WB) Protocol

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SKU	Supplier No.	Size	Your price	Quantity
BHA10558274	CSB-PA146106	100ul	$297		Add to Cart

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