Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.Warner J.P., Mamm. Genome 6:532-536(1995).Hayward B.E., Genomics 49:137-142(1998).Rieder M.J., Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human Glucokinase Regulator.
Raised In
Rabbit
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Relevance
Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
Warner J.P., Mamm. Genome 6:532-536(1995). Hayward B.E., Genomics 49:137-142(1998). Rieder M.J., Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total Glucokinase Regulator protein.