Cytosolic beta-glucosidase; EC 3.2.1.21; Cytosolic beta-glucosidase-like protein 1;
Categories
Primary Antibodies
Clonality
polyclonal
Description
Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.Yahata K., J. Mol. Med. 78:389-394(2000).de Graaf M., Biochem. J. 356:907-910(2001).Berrin J.-G., Eur. J. Biochem. 269:249-258(2002)
Host
Rabbit
Immunogen
Synthesized peptide derived from internal of Human GBA3.
Raised In
Rabbit
Reactivity
Human
Regulatory
RUO
Relevance
Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.
Yahata K., J. Mol. Med. 78:389-394(2000). de Graaf M., Biochem. J. 356:907-910(2001). Berrin J.-G., Eur. J. Biochem. 269:249-258(2002)
Species
Homo Sapiens (Human)
Specificity
The antibody detects endogenous levels of total GBA3 protein.
Glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. Able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. Possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.
Protein Families
Glycosyl hydrolase 1 family, Klotho subfamily
Tissue Specificity
Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas.
Buffer
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Format
liquid
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.